Further structural analysis of GnRH complexes with metal ions.
نویسندگان
چکیده
MALDI-TOF mass spectrometry, 1H NMR spectrometry, the continuous variation method and molecular modeling by MM3 calculation confirmed our earlier studies showing that gonadotropin-releasing hormone (GnRH) forms complex with copper(II) ion with the binding ratio 1:1. The copper(II) complex formed at physiological pH has a square planar configuration and GnRH complexes with nickel(II) and cobalt(II) ions are less stable than that of copper(II).
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ورودعنوان ژورنال:
- Neuro endocrinology letters
دوره 26 3 شماره
صفحات -
تاریخ انتشار 2005